Evaluating search and matching models using experimental data

This paper introduces an innovative test of search and matching models using the exogenous variation available in experimental data. We take an off-the-shelf Pissarides matching model and calibrate it to data on the control group from a randomized social experiment. We then simulate a program group from a randomized experiment within the model. As a measure of the performance of the model, we compare the outcomes of the program groups from the model and from the randomized experiment. We illustrate our methodology using the Canadian Self-Sufficiency Project (SSP), a social experiment providing a time limited earnings supplement for Income Assistance recipients who obtain full time employment within a 12 month period. We find two features of the model are consistent with the experimental results: endogenous search intensity and exogenous job destruction. We find mixed evidence in support of the assumption of fixed hours of labor supply. Finally, we find a constant job destruction rate is not consistent with the experimental data in this context

Cell seeding chamber for bone graft substitutes

There is an increasing demand for bone graft substitutes that are used as osteoconductive scaffolds in the treatment of bone defects and fractures. Achieving optimal bone regeneration requires initial cell seeding of the scaffolds prior to implantation. The cell seeding chamber is a closed assembly. It works like a sandglass. The position of the scaffold is between two reservoirs containing the fluid (e. g. blood). The fluid at the upper reservoir flows through the scaffold driven by gravity. Fluid is collected at the lower reservoir. If the upper reservoir is empty the whole assembly turned and the process starts again. A new compact cell seeding chamber for initial cell seeding has been developed that can be used in the operating theater

New computer system simplifies programming of mathematical equations

Automatic Mathematical Translator /AMSTRAN/ permits scientists or engineers to enter mathematical equations in their natural mathematical format and to obtain an immediate graphical display of the solution. This automatic-programming, on-line, multiterminal computer system allows experienced programmers to solve nonroutine problems

Domestic Violence, Employment and Divorce

Using unique, representative data on domestic violence, we document several stylized facts on abuse: the average characteristics of abused wives and abusive husbands are markedly different than the characteristics of individuals in non-violent marriages, the vast majority of violent marriages end in divorce, and employment rates are lower for women who experience abuse. We then construct a sequential model of employment, marriage and abuse. The results indicate abuse is the primary factor in the decision to divorce and witnessing violence as a child is a strong predictor of becoming an abusive spouse. Policy experiments suggest men are more responsive to policies designed to increase the costs of abuse than women are to policies reducing the cost of leaving violent marriages and policies designed to reduce the inter-generational effects of domestic violence may be promising strategies for preventing abuse.Domestic Violence, Abuse, Employment, Marriage, Divorce

Weak Lensing Reconstruction and Power Spectrum Estimation: Minimum Variance Methods

Large-scale structure distorts the images of background galaxies, which allows one to measure directly the projected distribution of dark matter in the universe and determine its power spectrum. Here we address the question of how to extract this information from the observations. We derive minimum variance estimators for projected density reconstruction and its power spectrum and apply them to simulated data sets, showing that they give a good agreement with the theoretical minimum variance expectations. The same estimator can also be applied to the cluster reconstruction, where it remains a useful reconstruction technique, although it is no longer optimal for every application. The method can be generalized to include nonlinear cluster reconstruction and photometric information on redshifts of background galaxies in the analysis. We also address the question of how to obtain directly the 3-d power spectrum from the weak lensing data. We derive a minimum variance quadratic estimator, which maximizes the likelihood function for the 3-d power spectrum and can be computed either from the measurements directly or from the 2-d power spectrum. The estimator correctly propagates the errors and provides a full correlation matrix of the estimates. It can be generalized to the case where redshift distribution depends on the galaxy photometric properties, which allows one to measure both the 3-d power spectrum and its time evolution.Comment: revised version, 36 pages, AAS LateX, submitted to Ap

On the Reverse Engineering of the Citadel Botnet

Citadel is an advanced information-stealing malware which targets financial information. This malware poses a real threat against the confidentiality and integrity of personal and business data. A joint operation was recently conducted by the FBI and the Microsoft Digital Crimes Unit in order to take down Citadel command-and-control servers. The operation caused some disruption in the botnet but has not stopped it completely. Due to the complex structure and advanced anti-reverse engineering techniques, the Citadel malware analysis process is both challenging and time-consuming. This allows cyber criminals to carry on with their attacks while the analysis is still in progress. In this paper, we present the results of the Citadel reverse engineering and provide additional insight into the functionality, inner workings, and open source components of the malware. In order to accelerate the reverse engineering process, we propose a clone-based analysis methodology. Citadel is an offspring of a previously analyzed malware called Zeus; thus, using the former as a reference, we can measure and quantify the similarities and differences of the new variant. Two types of code analysis techniques are provided in the methodology, namely assembly to source code matching and binary clone detection. The methodology can help reduce the number of functions requiring manual analysis. The analysis results prove that the approach is promising in Citadel malware analysis. Furthermore, the same approach is applicable to similar malware analysis scenarios.Comment: 10 pages, 17 figures. This is an updated / edited version of a paper appeared in FPS 201

The hyaluronan-binding serine protease from human plasma cleaves HMW and LMW kininogen and releases bradykinin

The influence of the hyaluronanbinding protease (PHBSP), a plasma enzyme with FVII- and pro-urokinase-activating potency, on components of the contact phase (kallikrein/kinin) system was investigated. No activation or cleavage of the proenzymes involved in the contact phase system was observed. The procofactor high molecular weight kininogen (HK), however, was cleaved in vitro by PHBSP in the absence of any charged surface, releasing the activated cofactor and the vasoactive nonapeptide bradykinin. Glycosoaminoglycans strongly enhanced the reaction. The cleavage was comparable to that of plasma kallikrein, but clearly different from that of coagulation factor FXIa. Upon extended incubation with PHBSP, the light chain was further processed, partially removing about 60 amino acid residues from the Nterminus of domain D5 of the light chain. These cleavage site(s) were distinct from plasma kallikrein or FXIa cleavage sites. PHBSP and, more interestingly, also plasma kallikrein could cleave low molecular weight kininogen in vitro, indicating that domains D5(H) and D6(H) are no prerequisite for kininogen cleavage. PHBSP was also able to release bradykinin from HK in plasma where the pro-cofactor circulates predominantly in complex with plasma kallikrein or FXI. In conclusion, PHBSP represents a novel kininogen-cleaving and bradykinin-releasing enzyme in plasma that shares significant catalytic similarities with plasma kallikrein. Since they are structurally unrelated in their heavy chains (propeptide), their similar in vivo catalytic activities might be directed at distinct sites where PHBSP could induce processes that are related to the kallikrein/kinin system

Microlensing events from the 11-year observations of the Wendelstein Calar Alto Pixellensing Project

We present the results of the decade-long M31 observation from the Wendelstein Calar Alto Pixellensing Project (WeCAPP). WeCAPP has monitored M31 from 1997 till 2008 in both R- and I-filters, thus provides the longest baseline of all M31 microlensing surveys. The data are analyzed with the difference imaging analysis, which is most suitable to study variability in crowded stellar fields. We extracted light curves based on each pixel, and devised selection criteria that are optimized to identify microlensing events. This leads to 10 new events, and sums up to a total of 12 microlensing events from WeCAPP, for which we derive their timescales, flux excesses, and colors from their light curves. The color of the lensed stars fall between (R-I) = 0.56 to 1.36, with a median of 1.0 mag, in agreement with our expectation that the sources are most likely bright, red stars at post main-sequence stage. The event FWHM timescales range from 0.5 to 14 days, with a median of 3 days, in good agreement with predictions based on the model of Riffeser et al. (2006).Comment: 44 pages, 16 figures, 5 tables. ApJ accepte